{"id":4505,"date":"2023-04-06T13:00:36","date_gmt":"2023-04-06T10:00:36","guid":{"rendered":"https:\/\/ekbilgi.net\/ozempic-aldim-sonra-pankreatit-oldum\/"},"modified":"2023-04-06T13:00:36","modified_gmt":"2023-04-06T10:00:36","slug":"ozempic-aldim-sonra-pankreatit-oldum","status":"publish","type":"post","link":"https:\/\/ekbilgi.net\/ozempic-aldim-sonra-pankreatit-oldum\/","title":{"rendered":"Ozempic ald\u0131m, sonra pankreatit oldum"},"content":{"rendered":"<article class=\"article-body css-d2znx6 undefined\">\n<div class=\"css-1u22pos\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<div><\/div>\n<div>\n<p class=\"css-1rnzyga\"><em>Ozempic&#8217;i \u00fc\u00e7 y\u0131l kulland\u0131ktan sonra, Dawn Gentle&#8217;a ilac\u0131n nadir fakat olas\u0131 bir yan etkisi olan pankreatit te\u015fhisi kondu.<\/em><\/p>\n<\/div>\n<div>\n<figure class=\"css-z8zrn2\"><span class=\"css-rwmw5v\"><span class=\"css-tx1uqz\"><picture class=\"css-16pk1is\"><source srcset=\"\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2023\/04\/female-rearview-1296x728-header-1296x729.jpg?w=1575 750w\" media=\"(min-width: 1190px)\"><\/source><source srcset=\"\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2023\/04\/female-rearview-1296x728-header-1296x729.jpg?w=1575 750w\" media=\"(min-width: 990px)\"><\/source><source srcset=\"\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2023\/04\/female-rearview-1296x728-header-1296x729.jpg?w=1845 879w\" media=\"(min-width: 768px)\"><\/source><\/picture><\/span><hl-share-overlay class=\"css-18moxll\"><span class=\"css-8yl26h\">Pinterest&#8217;te payla\u015f<\/span><\/hl-share-overlay><\/span><figcaption class=\"css-bx4197\">Nadir durumlarda, Ozempic pankreatit, b\u00f6brek komplikasyonlar\u0131 ve safra kesesi hastal\u0131\u011f\u0131 gibi ciddi yan etkilere neden olabilir.  Justin Paget\/Getty Images<\/figcaption><\/figure>\n<\/div>\n<p>2018&#8217;den 2021&#8217;e kadar Dawn Gentle, tip 2 diyabetini tedavi etmek i\u00e7in Ozempic&#8217;i ald\u0131.<\/p>\n<p>&#8220;Biraz kilo verdim ve seviyelerim normal seviyelere indi &#8211; bu k\u0131s\u0131m harikayd\u0131.  O s\u0131rada doktorum taraf\u0131ndan bana s\u00f6ylenmeyen \u015fey, hayat\u0131m\u0131 de\u011fi\u015ftirecek uzun s\u00fcreli yan etkilerdi&#8221; dedi.<\/p>\n<p>2021&#8217;de Gentle, a\u015f\u0131r\u0131 kar\u0131n a\u011fr\u0131s\u0131 nedeniyle acil servise ko\u015ftu.  Birka\u00e7 testten sonra kendisine pankreas iltihab\u0131 ile tan\u0131mlanan bir durum olan pankreatit te\u015fhisi kondu. <\/p>\n<p>Pankreas, sindirime yard\u0131mc\u0131 olan enzimleri salg\u0131layan bir organd\u0131r.  Ayr\u0131ca h\u00fccrelerinizin kan dola\u015f\u0131m\u0131ndan glikoz almas\u0131na yard\u0131mc\u0131 olan ins\u00fclin \u00fcretir ve serbest b\u0131rak\u0131r.<\/p>\n<p>Dr.  Rekha B. Kumar, Cornell&#8217;de t\u0131p profes\u00f6r\u00fc ve Found&#8217;da ba\u015f t\u0131p g\u00f6revlisi.<\/p>\n<p>Kumar, Healthline&#8217;a verdi\u011fi deme\u00e7te, &#8220;Pankreatit i\u00e7in di\u011fer risk fakt\u00f6rlerine sahip hastalarda &#8211; pankreatit \u00f6yk\u00fcs\u00fc, y\u00fcksek trigliseritler, y\u00fcksek alkol t\u00fcketimi veya pankreatite di\u011fer genetik yatk\u0131nl\u0131klar &#8211; nadir ve daha yayg\u0131nd\u0131r&#8221; dedi.<\/p>\n<p>Y\u00fcksek amilaz ve lipaz seviyeleri ile ilgili raporlar ve varsay\u0131msal olas\u0131l\u0131k olsa da, Dr.  Endokrinolog ve Amerikan Obezite T\u0131bb\u0131 Kurulu&#8217;ndan diplomat Karl Nadolsky: &#8220;Rastgele kontroll\u00fc \u00e7al\u0131\u015fmalarda ger\u00e7ek pankreatit insidans\u0131 \u00e7ok d\u00fc\u015f\u00fckt\u00fcr ve istatistiksel olarak nedensellik a\u00e7\u0131s\u0131ndan yetersizdir.&#8221;<\/p>\n<div class=\"css-umsscj\">\n<aside class=\"css-0 css-0\">\n<div>\n<div data-empty=\"true\" class=\"css-10gx9pb\">\n<div class=\"css-1hjaa0k\"><span class=\"css-zya54r\"><\/span><\/div>\n<div id=\"inline2__slot\" data-adbridg-ad-class=\"inline2__slot\" data-ad=\"true\" class=\" css-1l7cd95\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<\/div>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div><strong>Ozempic neden pankreatite neden olabilir?<\/strong><\/div>\n<\/h2>\n<p>Kumar, GLP-1 resept\u00f6r\u00fc agonistlerinin pankreatite neden olabilmesinin nedeni, ila\u00e7lar\u0131n pankreas\u0131 ins\u00fclin \u00fcretmesi i\u00e7in uyarmas\u0131d\u0131r, &#8220;bu nedenle zaten iltihapl\u0131 bir organda, bu birisini kenara itebilir&#8221; dedi Kumar.<\/p>\n<p>Ozempic, web sitesinde olas\u0131 ciddi bir yan etki olarak pankreatitten bahsediyor.  Ancak Gentle&#8217;\u0131n durumunda, olas\u0131l\u0131\u011f\u0131n fark\u0131nda de\u011fildi.<\/p>\n<p>&#8220;Bu yan etkiyi hastanenin acil servisine g\u00f6t\u00fcr\u00fcld\u00fckten sonra \u00f6\u011frendim.  Doktor bana \u015feker hastal\u0131\u011f\u0131m i\u00e7in hangi ilac\u0131 kulland\u0131\u011f\u0131m\u0131 sordu.  Ozempic&#8217;i ald\u0131\u011f\u0131n\u0131 kendisine bildirdi\u011fimde, &#8220;bu ilac\u0131 hemen almay\u0131 b\u0131rak&#8221; dedi.  Pankreatitime neden oldu&#8221; dedi.<\/p>\n<p>Sa\u011fl\u0131k personeli a\u011fr\u0131s\u0131n\u0131 kontrol alt\u0131na almak i\u00e7in \u00e7al\u0131\u015f\u0131rken bir hafta hastanede kald\u0131. <\/p>\n<p>Ayr\u0131ca te\u015fhis konuldu\u011fundan beri d\u00f6rt endoskopik retrograd kolanjiyopankreatografi (ERCP) prosed\u00fcr\u00fc ge\u00e7irdi.  Bir ERCP, te\u015fhis ve spesifik tedavilere yard\u0131mc\u0131 olmak i\u00e7in \u00fcst gastrointestinal (GI) endoskopi ve X-\u0131\u015f\u0131nlar\u0131n\u0131 birle\u015ftirir.<\/p>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div><strong>Pankreas Kanseri ile Ya\u015famak<\/strong><strong><\/strong><\/div>\n<\/h2>\n<p>Gentle, kar\u0131n a\u011fr\u0131s\u0131 nedeniyle test yap\u0131l\u0131rken daha ac\u0131 bir haber ald\u0131.  Sadece pankreatiti yoktu, ayn\u0131 zamanda doktorlar pankreas\u0131n\u0131n sonunda kanserli bir t\u00fcm\u00f6r ke\u015ffettiler.<\/p>\n<p>&#8220;Doktora ayn\u0131 zamanda Ozempic&#8217;in al\u0131nmas\u0131ndan kaynaklan\u0131p kaynaklanmad\u0131\u011f\u0131n\u0131 sordu\u011fumda, bunun olduk\u00e7a olas\u0131 oldu\u011funu s\u00f6yleme nezaketini g\u00f6sterdi&#8221; dedi.<\/p>\n<p>Ancak Kumar, ara\u015ft\u0131rman\u0131n \u015fu ana kadar GLP-1 ila\u00e7lar\u0131n\u0131n pankreas kanserine neden oldu\u011funu kan\u0131tlamad\u0131\u011f\u0131n\u0131 s\u00f6yledi.<\/p>\n<p>&#8220;Bu korelasyon, nedensellik de\u011fil.  \u0130yi ara\u015ft\u0131r\u0131lm\u0131\u015f&#8221; dedi.<\/p>\n<p>Ozempic, semaglutidin (Ozempic&#8217;in genel ad\u0131) kemirgenlerde tiroid C-h\u00fccresi t\u00fcm\u00f6rlerine neden oldu\u011funu belirtmektedir.  Bununla birlikte, semaglutidin neden oldu\u011fu kemirgen tiroid C-h\u00fccresi t\u00fcm\u00f6rlerinin insanlarla ili\u015fkisi belirlenmedi\u011finden, med\u00fcller tiroid karsinomu (MTC) dahil olmak \u00fczere insan tiroid C-h\u00fccresi t\u00fcm\u00f6rlerine neden olup olmad\u0131\u011f\u0131 bilinmemektedir.<\/p>\n<p>Nadolsky, kemirgenlerin \u00fczerinde insanlardan daha fazla tiroid C h\u00fccresi ve GLP-1 resept\u00f6r\u00fc oldu\u011funa dikkat \u00e7ekti.<\/p>\n<p>&#8220;Bu nedenle, neden [GLP-1 medicines] Kendisinde veya ailesinde med\u00fcller tiroid kanseri veya MENT 2a\/b \u00f6yk\u00fcs\u00fc olan hastalarda \u00f6nerilmemektedir&#8221; dedi.  &#8220;Yaln\u0131zca yak\u0131n tarihli bir vaka kontrol \u00e7al\u0131\u015fmas\u0131 med\u00fcller ve di\u011fer tiroid kanserleri i\u00e7in risk g\u00f6sterdi\u011finden, ancak ki\u015fisel veya aile tiroid kanseri \u00f6yk\u00fcs\u00fc gibi belirli ve \u00f6nemli risk fakt\u00f6rleri i\u00e7in kontrol olmad\u0131\u011f\u0131ndan, bu insanlarda i\u015fe yaramad\u0131.&#8221;<\/p>\n<p>Mevcut ara\u015ft\u0131rmalar bu t\u00fcr ila\u00e7lar\u0131n pankreas kanserine (PC) neden olmad\u0131\u011f\u0131n\u0131 g\u00f6sterse de, baz\u0131 ara\u015ft\u0131rmac\u0131lar kesin sonu\u00e7lara varmak i\u00e7in daha fazla ara\u015ft\u0131rma yap\u0131lmas\u0131n\u0131 istiyor.<\/p>\n<p>\u00d6rne\u011fin bir 2022 <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\">g\u00f6zden ge\u00e7irmek<\/hl-trusted-source> yay\u0131nlanan konuyla ilgili mevcut literat\u00fcr <em>D\u00fcnya Gastroenteroloji Dergisi<\/em> &#8220;PC&#8217;nin belirsiz riskleri, inkretin bazl\u0131 tedavilerin yararl\u0131 pleiotropik etkilerine k\u0131yasla azalm\u0131\u015f gibi g\u00f6r\u00fcnse de &#8230; daha yeni incretin bazl\u0131 tedavilerle PC&#8217;nin teorik olas\u0131l\u0131\u011f\u0131n\u0131 akl\u0131m\u0131zda tutmal\u0131 ve yeterli bilgiye sahip olana kadar dikkatli olmal\u0131y\u0131z. .&#8221; veri ald\u0131.&#8221;<\/p>\n<p>Gentle&#8217;\u0131n deneyimine g\u00f6re, tip 2 diyabetini tedavi etmek i\u00e7in Ozempic ald\u0131\u011f\u0131na pi\u015fman.<\/p>\n<p>\u201cHangi yan etkilerin oldu\u011funu ve ne kadar \u015fiddetli oldu\u011funu bilseydim [they could be]Bunun i\u00e7in asla gitmezdim&#8221; dedi.<\/p>\n<p>Gentle vakas\u0131 nadir olmakla birlikte, Ozempic almadan \u00f6nce dikkate al\u0131nmas\u0131 gereken bir tak\u0131m yan etkiler vard\u0131r.<\/p>\n<p>\u201c\u0130nsanlar riskleri tartmal\u0131 [versus] Herhangi bir re\u00e7eteli veya re\u00e7etesiz ila\u00e7 almadan \u00f6nce, doktorunuzun rehberli\u011finde t\u00fcm ila\u00e7lar\u0131n faydalar\u0131n\u0131 ve yan etki risklerini anlay\u0131n.  Ozempic bir istisna de\u011fil,&#8221; dedi Kumar.<\/p>\n<div class=\"wp-block-healthline-jwplayer\">\n<div class=\"css-1q447m2\">\n<div class=\"css-oup8q3\"><svg viewbox=\"0 0 16 9\" class=\"css-xcxd8t\"><\/svg><\/div>\n<\/div>\n<\/div>\n<p><span class=\"css-zya54r\"><\/span><\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div><strong>Ozempic&#8217;in ciddi yan etkileri<\/strong><\/div>\n<\/h2>\n<p>Gentle&#8217;s gibi nadir durumlarda, Ozempic ciddi yan etkilere neden olabilir.  Pankreatite ek olarak, a\u015fa\u011f\u0131daki yan etkiler de m\u00fcmk\u00fcnd\u00fcr:<\/p>\n<ul>\n<li>D\u00fc\u015f\u00fck kan \u015fekeri (hipoglisemi)<\/li>\n<li>Alerjik reaksiyon<\/li>\n<li>Diyabetik retinopati (g\u00f6rme kayb\u0131na neden olabilen bir g\u00f6z hastal\u0131\u011f\u0131)<\/li>\n<li>b\u00f6brek komplikasyonlar\u0131<\/li>\n<li>safra kesesi hastal\u0131\u011f\u0131<\/li>\n<\/ul>\n<p>Nadolsky, &#8220;\u0130statistiksel olarak anlaml\u0131, ancak yine \u00e7ok d\u00fc\u015f\u00fck bir mutlak safra kesesi hastal\u0131\u011f\u0131 riski var ve bu, di\u011fer prosed\u00fcrlerden \u00f6nemli kilo kayb\u0131yla da ortaya \u00e7\u0131k\u0131yor&#8221; dedi.<\/p>\n<p>O bir i\u015faret etti <hl-trusted-source source=\"PubMed Central\" rationale=\"Highly respected database from the National Institutes of Health\">meta-analiz<\/hl-trusted-source> GLP-1 RA kullan\u0131m\u0131n\u0131n, \u00f6zellikle daha y\u00fcksek dozlarda, daha uzun s\u00fcre ve kilo kayb\u0131 i\u00e7in kullan\u0131ld\u0131\u011f\u0131nda, artan safra kesesi veya safra yolu hastal\u0131\u011f\u0131 riski ile ili\u015fkili oldu\u011funu bulan RK\u00c7&#8217;lerin oran\u0131.<\/p>\n<div class=\"css-1cg0byz\">\n<aside class=\"css-0 css-0\">\n<div>\n<div data-empty=\"true\" class=\"css-az6x7v\">\n<div class=\"css-1hjaa0k\"><span class=\"css-zya54r\"><\/span><\/div>\n<div id=\"inline9__slot\" data-adbridg-ad-class=\"inline9__slot\" data-ad=\"true\" class=\" css-itezwm\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<\/div>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div><strong>Ozempic&#8217;in hafif ve yayg\u0131n yan etkileri<\/strong><\/div>\n<\/h2>\n<p>Ozempic ayr\u0131ca a\u015fa\u011f\u0131daki hafif yan etkilere de neden olabilir:<\/p>\n<ul>\n<li>ge\u011firme, gaz, mide rahats\u0131zl\u0131\u011f\u0131 veya mide ek\u015fimesi<\/li>\n<li>kab\u0131zl\u0131k veya ishal<\/li>\n<li>ba\u015f d\u00f6nmesi<\/li>\n<li>Ba\u015f a\u011fr\u0131s\u0131<\/li>\n<li>g\u00f6\u011f\u00fcste a\u011fr\u0131l\u0131 yanma hissi<\/li>\n<li>Kalp at\u0131\u015f h\u0131z\u0131nda hafif art\u0131\u015f<\/li>\n<li>mide bulant\u0131s\u0131 ya da kusma<\/li>\n<li>kar\u0131n a\u011fr\u0131s\u0131<\/li>\n<li>Tat de\u011fi\u015fiklikleri veya i\u015ftah kayb\u0131<\/li>\n<li>t\u00fckenmi\u015flik<\/li>\n<li>K\u0131zar\u0131kl\u0131k, renk de\u011fi\u015fikli\u011fi veya rahats\u0131zl\u0131k dahil olmak \u00fczere enjeksiyon b\u00f6lgesi reaksiyonlar\u0131<\/li>\n<\/ul>\n<p>Kumar, &#8220;Hastalar, ciddi yan etkiler olup olmad\u0131\u011f\u0131n\u0131 ve ilac\u0131n kesilmesi gerekip gerekmedi\u011fini belirlemek i\u00e7in herhangi bir yan etkiyi doktorlar\u0131na bildirmelidir.&#8221; Dedi.<\/p>\n<p>Ciddi olmayan yan etkileri y\u00f6netmek i\u00e7in se\u00e7eneklerin, dozu azaltmay\u0131 veya dozu art\u0131rmamay\u0131 normal y\u00fckseltme plan\u0131na g\u00f6re i\u00e7erebilece\u011fini s\u00f6yledi.<\/p>\n<p>Kumar, &#8220;Bir ilac\u0131n yarar\u0131n\u0131n riskten a\u011f\u0131r bast\u0131\u011f\u0131 ve yan etkiyi vaka baz\u0131nda bir antasit veya antiemetik ile ge\u00e7ici olarak tedavi etti\u011fi zamanlar olabilir.&#8221; Dedi.<\/p>\n<p>Nadolsky kabul etti.  Genel olarak, kilo vermenin kardiyometabolik yararlar\u0131, glisemik kontrol, kardiyovask\u00fcler yararlar ve GLP-1 ila\u00e7lar\u0131n\u0131n sa\u011flayabilece\u011fi b\u00f6brek yararlar\u0131, obezitesi olan hastalardaki risklerden daha a\u011f\u0131r basar &#8220;ve \u00f6zellikle obezitesi olan ve \u015fiddetli hastalarda, bu gibi komplikasyonlarla \u00f6l\u00e7\u00fcld\u00fc\u011f\u00fc \u00fczere&#8221; Tip 2 diyabet, metabolik sendrom ve kardiyovask\u00fcler hastal\u0131k gibi.\u201d<\/p>\n<\/div>\n<\/article>\n<p>Daha \u00e7ok <a href=\"https:\/\/ekbilgi.net\/saglik\/\">sa\u011fl\u0131k<\/a> yaz\u0131s\u0131 okumak i\u00e7in kategorimize g\u00f6z atabilirsiniz.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ozempic&#8217;i \u00fc\u00e7 y\u0131l kulland\u0131ktan sonra, Dawn Gentle&#8217;a ilac\u0131n nadir fakat olas\u0131 bir yan etkisi olan pankreatit te\u015fhisi kondu. Pinterest&#8217;te payla\u015fNadir durumlarda, Ozempic pankreatit, b\u00f6brek komplikasyonlar\u0131 ve safra kesesi hastal\u0131\u011f\u0131 gibi ciddi yan etkilere neden olabilir&#8230;.<\/p>\n","protected":false},"author":2,"featured_media":4506,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[135],"tags":[433,3805,3808,3802,3806,391,3814,3801,3815,749,3816,3560,3803,3800,3809,3813,3810,3812,3811,3804,1589,575,3807,520],"_links":{"self":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/posts\/4505"}],"collection":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/comments?post=4505"}],"version-history":[{"count":0,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/posts\/4505\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/media\/4506"}],"wp:attachment":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/media?parent=4505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/categories?post=4505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/tags?post=4505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}