{"id":7747,"date":"2023-12-07T10:00:09","date_gmt":"2023-12-07T07:00:09","guid":{"rendered":"https:\/\/ekbilgi.net\/statinler-kronik-bobrek-hastaligi-olan-yasli-yetiskinlerde-olum-riskini-azaltir\/"},"modified":"2023-12-07T10:00:09","modified_gmt":"2023-12-07T07:00:09","slug":"statinler-kronik-bobrek-hastaligi-olan-yasli-yetiskinlerde-olum-riskini-azaltir","status":"publish","type":"post","link":"https:\/\/ekbilgi.net\/statinler-kronik-bobrek-hastaligi-olan-yasli-yetiskinlerde-olum-riskini-azaltir\/","title":{"rendered":"Statinler kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ya\u015fl\u0131 yeti\u015fkinlerde \u00f6l\u00fcm riskini azalt\u0131r"},"content":{"rendered":"<div class=\"css-1u22pos\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<div><\/div>\n<p><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<div>\n<figure class=\"css-z8zrn2\"><span class=\"css-rwmw5v\"><span class=\"css-tx1uqz\"><picture class=\"css-16pk1is\"><source srcset=\"https:\/\/ekbilgi.net\/wp-content\/uploads\/2023\/12\/Statinler-kronik-bobrek-hastaligi-olan-yasli-yetiskinlerde-olum-riskini-azaltir.jpg 750w\" media=\"(min-width: 1190px)\"><\/source><source srcset=\"https:\/\/ekbilgi.net\/wp-content\/uploads\/2023\/12\/Statinler-kronik-bobrek-hastaligi-olan-yasli-yetiskinlerde-olum-riskini-azaltir.jpg 750w\" media=\"(min-width: 990px)\"><\/source><source srcset=\"https:\/\/ekbilgi.net\/wp-content\/uploads\/2023\/12\/Statinler-kronik-bobrek-hastaligi-olan-yasli-yetiskinlerde-olum-riskini-azaltir.jpg 879w\" media=\"(min-width: 768px)\"><\/source><\/picture><\/span><hl-share-overlay class=\"css-18moxll\"><span class=\"css-8yl26h\">Pinterest&#8217;te Payla\u015f<\/span><\/hl-share-overlay><\/span><figcaption class=\"css-bx4197\">Statin almak, kolesterol\u00fc y\u00fcksek olmasa bile insanlara yard\u0131mc\u0131 oluyor gibi g\u00f6r\u00fcn\u00fcyordu.  Grace Cary\/Getty Images<\/figcaption><\/figure>\n<\/div>\n<ul>\n<li><strong>Yeni bir \u00e7al\u0131\u015fma, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ve kolesterol d\u00fc\u015f\u00fcr\u00fcc\u00fc statin alan ya\u015fl\u0131 yeti\u015fkinlerin herhangi bir nedenden \u00f6lme riskinin daha d\u00fc\u015f\u00fck oldu\u011funu buldu.<\/strong><\/li>\n<li><strong>Ara\u015ft\u0131rmaya kat\u0131lanlar\u0131n herhangi bir kardiyovask\u00fcler hastal\u0131k \u00f6yk\u00fcs\u00fc yoktu.  Bu t\u00fcr statin kullan\u0131m\u0131na birincil korunma denir.<\/strong><\/li>\n<li><strong>Uzmanlar, ara\u015ft\u0131rman\u0131n \u00e7o\u011funlukla ya\u015fl\u0131 beyaz erkekleri kapsad\u0131\u011f\u0131n\u0131, dolay\u0131s\u0131yla sonu\u00e7lar\u0131n kad\u0131nlar veya \u0131rksal\/etnik az\u0131nl\u0131klar i\u00e7in ge\u00e7erli olmayabilece\u011fini belirtiyor.<\/strong><\/li>\n<\/ul>\n<div data-preamp=\"serena-chatbot\"><\/div>\n<p>Yeni bir \u00e7al\u0131\u015fma, y\u00fcksek kolesterol\u00fc tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lan bir ila\u00e7 s\u0131n\u0131f\u0131 olan statinlerin, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ancak aterosklerotik kardiyovask\u00fcler hastal\u0131k \u00f6yk\u00fcs\u00fc olmayan ya\u015fl\u0131 yeti\u015fkinlerde \u00f6l\u00fcm riskini azaltt\u0131\u011f\u0131n\u0131 buldu.<\/p>\n<p><hl-trusted-source source=\"American Heart Associaiton\" rationale=\"Highly respected national organization\">Aterosklerotik kardiyovask\u00fcler hastal\u0131k<\/hl-trusted-source>Ateroskleroz olarak da adland\u0131r\u0131lan bu hastal\u0131kta, atardamarlar\u0131n i\u00e7 duvarlar\u0131nda plak ad\u0131 verilen ya\u011f birikintileri olu\u015fur.<\/p>\n<p>\u00c7al\u0131\u015fma 6 Aral\u0131k&#8217;ta yay\u0131nland\u0131 <hl-trusted-source source=\"JAMA\" rationale=\"Highly respected journal,Expert written journal,Peer reviewed journal\"><em>JAMA a\u011f\u0131 a\u00e7\u0131ld\u0131<\/em><\/hl-trusted-source>Ara\u015ft\u0131rmac\u0131lar, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ki\u015filerde birincil korunma i\u00e7in statin kullanman\u0131n faydalar\u0131n\u0131 g\u00f6steren \u00f6nceki ara\u015ft\u0131rmalar\u0131 destekledi\u011fini yazd\u0131.<\/p>\n<p>Birincil korunma, kardiyovask\u00fcler hastal\u0131k \u00f6yk\u00fcs\u00fc olmayan ki\u015filerde statinlerin kullan\u0131lmas\u0131d\u0131r.  Amerika Birle\u015fik Devletleri \u00d6nleyici Hizmetler G\u00f6rev G\u00fcc\u00fc (USPSTF), bu yakla\u015f\u0131m\u0131, kardiyovask\u00fcler hastal\u0131k geli\u015ftirme riski daha y\u00fcksek olan belirli yeti\u015fkinler i\u00e7in \u00f6nermektedir.<\/p>\n<p>Mevcut klinik k\u0131lavuzlar, orta derecede kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ki\u015filerin, aterosklerotik kardiyovask\u00fcler hastal\u0131k riskleri nedeniyle statinlerle tedaviye ba\u015flamas\u0131n\u0131 \u00f6nermektedir.<\/p>\n<p>Ara\u015ft\u0131rmac\u0131lar, &#8220;Ancak, k\u0131lavuzlar birincil ve ikincil korunma aras\u0131nda veya kardiyovask\u00fcler hastal\u0131k \u00f6yk\u00fcs\u00fc olanlar aras\u0131nda ayr\u0131m yapm\u0131yor&#8221; diye yaz\u0131yor.<\/p>\n<p>&#8220;Bu \u00e7al\u0131\u015fma, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan hastalarda koruyucu bak\u0131m\u0131n \u00f6nemini vurgulamaktad\u0131r&#8221; dedi Dr.  Yeni \u00e7al\u0131\u015fmaya dahil olmayan, b\u00f6brek bak\u0131m \u015firketi Somatus&#8217;ta kardiyolog ve t\u0131bbi y\u00f6netimden sorumlu k\u0131demli ba\u015fkan yard\u0131mc\u0131s\u0131 Jesse Yang.<\/p>\n<p>Healthline&#8217;a \u015funlar\u0131 s\u00f6yledi: &#8220;Statinler, di\u011fer \u00f6nleyici tedbirlerle birlikte, risk alt\u0131ndaki bu hastalar i\u00e7in olumsuz sonu\u00e7lar\u0131 \u00f6nlemeye ve daha sa\u011fl\u0131kl\u0131, daha uzun ya\u015famalar\u0131na yard\u0131mc\u0131 olmaya hizmet ediyor.&#8221;<\/p>\n<div class=\"css-20w1gi\">\n<aside class=\"css-0 css-0\" data-testid=\"sticky-inline-ad\" data-sticky=\"false\">\n<div>\n<div data-empty=\"true\" class=\"css-1sq15os\">\n<div class=\"css-1hjaa0k\"><span class=\"css-zya54r\"><\/span><\/div>\n<div id=\"inline2__slot\" data-adbridg-ad-class=\"inline2__slot\" data-ad=\"true\" class=\" css-1t05dkn\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<\/div>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div>Herhangi bir nedenden dolay\u0131 \u00f6l\u00fcm riskinin daha d\u00fc\u015f\u00fck olmas\u0131<\/div>\n<\/h2>\n<p><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<p>Kronik b\u00f6brek hastal\u0131\u011f\u0131 olan 65 ya\u015f \u00fcst\u00fc 14.828 ki\u015fi \u00fczerinde yap\u0131lan ara\u015ft\u0131rmada ara\u015ft\u0131rmac\u0131lar, statin alman\u0131n herhangi bir nedenden dolay\u0131 \u00f6l\u00fcm riskini %9 oran\u0131nda azaltt\u0131\u011f\u0131n\u0131 buldu.<\/p>\n<p>Statin alan ki\u015filerde kalp krizi veya fel\u00e7 gibi \u00f6nemli kardiyovask\u00fcler olaylara yakalanma riski de %4 daha d\u00fc\u015f\u00fckt\u00fc.  Ancak bu fark istatistiksel olarak anlaml\u0131 de\u011fildi.<\/p>\n<p>Veriler Gaziler \u0130\u015fleri (VA) sa\u011fl\u0131k sisteminden geliyor. <\/p>\n<p>Dr.  Bradley Serwer, hastanelere kardiyovask\u00fcler ve anesteziyoloji hizmetleri sa\u011flayan VitalSolution&#8217;da giri\u015fimsel kardiyolog ve ba\u015f t\u0131bbi g\u00f6revlidir. <\/p>\n<p>Sewer, VA&#8217;n\u0131n &#8220;y\u0131llard\u0131r t\u0131bbi ara\u015ft\u0131rmalar\u0131n \u00f6nde gelen kayna\u011f\u0131 oldu\u011funu&#8221; belirtti.<\/p>\n<p>Bununla birlikte, ara\u015ft\u0131rmaya kat\u0131lanlar a\u011f\u0131rl\u0131kl\u0131 olarak ortalama 74 ya\u015f\u0131nda olan beyaz erkeklerden olu\u015fuyordu.  Serwer, Healthline&#8217;a bu nedenle sonu\u00e7lar\u0131n kad\u0131nlar veya \u0131rksal ve etnik az\u0131nl\u0131klar gibi di\u011fer gruplar i\u00e7in ge\u00e7erli olmayabilece\u011fini s\u00f6yledi.<\/p>\n<p>Ek olarak, &#8220;Bu \u00e7al\u0131\u015fma, optimal sonucu belirlemek i\u00e7in statin tedavisinin dozunu veya s\u00fcresini de\u011ferlendirmedi&#8221; dedi.<\/p>\n<p>Ve \u00e7al\u0131\u015fma g\u00f6zlemsel oldu\u011fundan statin alan kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ki\u015filerin daha uzun ya\u015fad\u0131\u011f\u0131n\u0131 kan\u0131tlam\u0131yor.  Yeni ara\u015ft\u0131rmaya dahil olmayan Serwer, &#8220;Bu, statin almaya ba\u015flayanlar aras\u0131nda t\u00fcm nedenlere ba\u011fl\u0131 \u00f6l\u00fcm oranlar\u0131n\u0131n daha d\u00fc\u015f\u00fck oldu\u011fu bir ili\u015fkinin oldu\u011funu g\u00f6steriyor&#8221; dedi.<\/p>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div>Statinler kardiyovask\u00fcler hastal\u0131klar\u0131 \u00f6nler<\/div>\n<\/h2>\n<p><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<p>\u00c7al\u0131\u015fma ayr\u0131ca statin alan ki\u015filerin \u00f6l\u00fcm riskinin neden daha d\u00fc\u015f\u00fck oldu\u011funu da spesifik olarak incelemedi.  Ancak Serwer, &#8220;Statinlerin sadece kolesterol\u00fc d\u00fc\u015f\u00fcrmenin \u00f6tesinde bir\u00e7ok faydaya sahip oldu\u011funu \u00e7ok say\u0131da ba\u015fka \u00e7al\u0131\u015fmadan biliyoruz&#8221; dedi.<\/p>\n<p>&#8220;Statin ila\u00e7lar\u0131, kolesterol\u00fc d\u00fc\u015f\u00fcrse de d\u00fc\u015f\u00fcrmese de fel\u00e7 ve kalp krizi oranlar\u0131n\u0131 azaltma yetene\u011fine sahip&#8221; dedi.  &#8220;Ve statinler kan damarlar\u0131n\u0131 stabilize etmeye ve plak olu\u015fumunu ve plak par\u00e7alanmas\u0131n\u0131 \u00f6nlemeye yard\u0131mc\u0131 olur.&#8221;<\/p>\n<p>Yang ayr\u0131ca, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ki\u015filerin y\u00fcksek tansiyon ve diyabet gibi kronik hastal\u0131klara yakalanma riskinin daha y\u00fcksek oldu\u011funu ve bunun da kardiyovask\u00fcler hastal\u0131klar\u0131n daha erken geli\u015fmesine yol a\u00e7abilece\u011fini s\u00f6yledi. <\/p>\n<p>Bunun ins\u00fclin direnci ve dislipidemi riskini veya kandaki bir veya daha fazla ya\u011f t\u00fcr\u00fcn\u00fcn sa\u011fl\u0131ks\u0131z seviyelerini art\u0131rabilece\u011fini s\u00f6yledi.<\/p>\n<p>&#8220;Metabolik sendromlu hastalarda statinlerin kardiyovask\u00fcler hastal\u0131klar\u0131 \u00f6nlemede kan\u0131tlanm\u0131\u015f etkisi, \u00e7al\u0131\u015fma hastalar\u0131nda muhtemelen daha d\u00fc\u015f\u00fck kardiyovask\u00fcler olay ve \u00f6l\u00fcm oranlar\u0131yla sonu\u00e7land\u0131&#8221; dedi.<\/p>\n<p>Ara\u015ft\u0131rmac\u0131lar bulgular\u0131n\u0131 do\u011frulamak i\u00e7in ek ara\u015ft\u0131rmalara, \u00f6zellikle de randomize bir klinik ara\u015ft\u0131rmaya ihtiya\u00e7 oldu\u011funu yaz\u0131yor.<\/p>\n<p>Ancak sonu\u00e7lar, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ve kardiyovask\u00fcler hastal\u0131k \u00f6yk\u00fcs\u00fc olmayan ya\u015fl\u0131 hastalarda statin tedavisinin durdurulmas\u0131na veya durdurulmas\u0131na kar\u015f\u0131 tavsiyede bulunuldu\u011funu belirtti.<\/p>\n<div class=\"css-umsscj\">\n<aside class=\"css-0 css-0\" data-testid=\"sticky-inline-ad\" data-sticky=\"false\">\n<div>\n<div data-empty=\"true\" class=\"css-10gx9pb\">\n<div class=\"css-1hjaa0k\"><span class=\"css-zya54r\"><\/span><\/div>\n<div id=\"inline7__slot\" data-adbridg-ad-class=\"inline7__slot\" data-ad=\"true\" class=\" css-1l7cd95\"><\/div>\n<\/div>\n<\/div>\n<\/aside>\n<\/div>\n<\/div>\n<div class=\"css-0\"><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<h2>\n<div>Getir<\/div>\n<\/h2>\n<p><span style=\"font-size:0;line-height:0\"><\/span><\/p>\n<p>Ara\u015ft\u0131rmac\u0131lar, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ve kardiyovask\u00fcler hastal\u0131k \u00f6yk\u00fcs\u00fc olmayan 14.000&#8217;den fazla ya\u015fl\u0131 yeti\u015fkinin verilerini inceledi.  Kolesterol\u00fc d\u00fc\u015f\u00fcrmek i\u00e7in kullan\u0131lan bir ila\u00e7 s\u0131n\u0131f\u0131 olan statin kullananlar\u0131n herhangi bir nedenden \u00f6lme riski daha d\u00fc\u015f\u00fckt\u00fc.<\/p>\n<p>Klinik k\u0131lavuzlar, aterosklerotik kardiyovask\u00fcler hastal\u0131k riski nedeniyle orta derecede kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ki\u015filerde statinlerin kullan\u0131lmas\u0131n\u0131 \u00f6nermektedir.  Bu \u00e7al\u0131\u015fma bu pop\u00fclasyonda statinlerin faydalar\u0131n\u0131 vurgulamaktad\u0131r.<\/p>\n<p>Sonu\u00e7lar\u0131n do\u011frulanmas\u0131 i\u00e7in randomize bir klinik \u00e7al\u0131\u015fma da dahil olmak \u00fczere daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.  Statin kullan\u0131m\u0131n\u0131n t\u00fcm gruplara e\u015fit fayda sa\u011flay\u0131p sa\u011flamad\u0131\u011f\u0131n\u0131 belirlemek i\u00e7in daha \u00e7e\u015fitli bir pop\u00fclasyonda ara\u015ft\u0131rma yap\u0131lmas\u0131na da ihtiya\u00e7 vard\u0131r.<\/p>\n<\/div>\n<p>Daha \u00e7ok <a href=\"https:\/\/ekbilgi.net\/saglik\/\">sa\u011fl\u0131k<\/a> yaz\u0131s\u0131 okumak i\u00e7in kategorimize g\u00f6z atabilirsiniz.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pinterest&#8217;te Payla\u015fStatin almak, kolesterol\u00fc y\u00fcksek olmasa bile insanlara yard\u0131mc\u0131 oluyor gibi g\u00f6r\u00fcn\u00fcyordu. Grace Cary\/Getty Images Yeni bir \u00e7al\u0131\u015fma, kronik b\u00f6brek hastal\u0131\u011f\u0131 olan ve kolesterol d\u00fc\u015f\u00fcr\u00fcc\u00fc statin alan ya\u015fl\u0131 yeti\u015fkinlerin herhangi bir nedenden \u00f6lme riskinin daha&#8230;<\/p>\n","protected":false},"author":2,"featured_media":7748,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[135],"tags":[384],"_links":{"self":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/posts\/7747"}],"collection":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/comments?post=7747"}],"version-history":[{"count":0,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/posts\/7747\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/media\/7748"}],"wp:attachment":[{"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/media?parent=7747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/categories?post=7747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ekbilgi.net\/wp-json\/wp\/v2\/tags?post=7747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}